Myo-Inositol + D-Chiro-Inositol
40:1 ratio. Superior to metformin for restoring ovulation and reducing testosterone in clinical trials.
2g myo + 50mg D-chiro, twice daily
Magnesium Glycinate
Insulin receptor cofactor. Deficiency is near-universal in insulin-resistant PCOS.
300-400mg evening
Vitamin D3 + K2
Regulates insulin sensitivity and ovarian function. Deficiency is found in over 70% of PCOS patients.
5000 IU D3 + 100mcg K2 daily
NAC (N-Acetyl Cysteine)
Improves insulin sensitivity and reduces testosterone in PCOS. Also supports glutathione — the primary liver detox antioxidant.
600mg twice daily with food
Omega-3 EPA/DHA
Reduces systemic inflammation driving insulin resistance. Improves egg quality.
2g daily with food
Berberine
Comparable to metformin for insulin sensitisation. Activates AMPK pathway reducing hepatic glucose output.
500mg 3x daily with meals
DIM (Diindolylmethane)
Supports estrogen detox through the liver — reducing the estrogen dominance that amplifies PCOS symptoms.
200-400mg daily with food